How Long Does Compounded Tirzepatide Last In Fridge?

Typically, compounded Tirzepatide should be stored in the refrigerator at 2°C to 8°C (35°F to 46°F) and is usually stable for a period that can range from a few weeks up to 90 days when properly stored. It's important to follow specific storage guidelines provided by the pharmacy that compounded the medication, as these can differ depending on the excipients used and the packaging.

Understanding Compounded Tirzepatide

Compounded tirzepatide is a customized version of the medication used for treating type 2 diabetes and managing obesity. It allows for tailored dosing and ingredient combinations to meet individual patient needs, which can optimize treatment outcomes and reduce side effects. Adding ingredients like Vitamin B12 can enhance energy levels and improve metabolic health, which can be particularly beneficial for managing the side effects like nausea often associated with tirzepatide.

Patients considering compounded tirzepatide should be aware that unlike FDA-approved versions like Mounjaro, compounded tirzepatide hasn't undergone the same rigorous testing and approval processes. This lack of FDA approval raises questions about consistency, efficacy, and safety. Therefore, it's crucial to source this medication from reputable compounding pharmacies to ensure quality and effectiveness.

Compounded tirzepatide is beneficial for patients with specific dosage requirements, sensitivities to standard formulations, or those needing to combine multiple medications into a simpler treatment regimen.

Factors Affecting Tirzepatide Stability in the Fridge

Tirzepatide stability in the fridge is essential to maintain its effectiveness for managing diabetes or aiding in weight loss. Here are the key factors affecting its stability:

• Temperature: Tirzepatide should be stored in the refrigerator at a temperature range between 36°F and 46°F (2°C and 8°C). If tirzepatide is exposed to temperatures above 86°F (30°C) or below freezing, it can degrade and become less effective.
• Duration Outside the Fridge: Once removed from the fridge, tirzepatide can be kept at room temperature, up to 86°F (30°C), for a maximum of 21 days. It should not be used if it has been left out longer than this period, as it may lose its potency.
• Light Exposure: Tirzepatide should be protected from direct light, which can also degrade its potency. Keeping it in its original packaging can help shield it from light.
• Handling and Usage: When using tirzepatide, it's important to check the expiry date and inspect the pen or vial for any abnormalities like discoloration or particulate matter. Use the medication promptly within the 21-day window after removal from refrigeration and administer it using proper techniques.

Recommended Shelf Life of Tirzepatide in Refrigeration

The shelf life of tirzepatide when refrigerated properly is typically up to 18 months from the manufacturing date, as indicated on the label. However, it is vital to check the expiration date provided by the manufacturer to ensure its potency. Unused tirzepatide pens must remain in the fridge and be discarded if frozen. Once opened and used, the pens should not return to the fridge and need to be used within 30 days to ensure safety and efficacy.

If tirzepatide is not stored under the recommended conditions, its peptide structure may degrade, reducing its effectiveness for treating conditions like diabetes or assisting in weight management.

Tips to Ensure Optimal Potency of Compounded Tirzepatide

• Manage Room Temperature Exposure: If you need to keep tirzepatide out of the refrigerator, it can stay at room temperature (up to 30°C or 86°F) for a maximum of 21 days. Always track how long the medication has been out of the refrigerator to ensure it hasn’t exceeded this limit.
• Travel Safely: When traveling, carry tirzepatide in an insulated bag with gel packs to maintain the correct temperature. Ensure the medication does not come into direct contact with ice packs to prevent freezing.
• Check Expiry Dates: Regularly check the expiration date on your tirzepatide packaging. Using expired medication can be ineffective and unsafe.
• Proper Disposal: Dispose of expired or unused tirzepatide properly. Many pharmacies offer medication take-back programs which are a safe disposal option.